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An injured man walks, with police, from a house where there was an explosion. (Dani Mario/CBC)

A house in Regina shook from the force of an explosion that injured two men, according to people who live in the Cathedral neighbourhood where it happened.

Fire crews, EMS and police rushed to the scene, on 13th Avenue near Athol Street, around 8 p.m. CST Monday.

An official with the Regina Fire department confirmed there was an explosion and smoke from a small fire.

The official said two men in the home suffered burns to their arms, although the precise extent of their injuries was not known.

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"I heard this great big 'whomp'," Daryl Eberhardt, who lives nearby, told CBC News Monday night. "It was just like something hit you in the stomach."

Eberhardt said it sounded like a car hit her house but when she went outside to check, it was clear that something else had happened.

According to Eberhardt, another neighbour rushed into the home where the explosion took place and put out a small fire that started.

"We don't know exactly what's happened over there," she said, adding there were unusual odors in the air that she could not identify.

Police blocked off 13th Avenue, between Athol and Garnet Monday night.

There was no immediate word from the fire department on the cause, but on Tuesday morning, officials said they were investigating a possible "cooking-related" incident.