A man and a woman from Aylmer are dead and another woman is seriously injured after a crash on Highway 148 just west of Luskville, Que.

It happened before 9 a.m. at the intersection of Highway 148 and Thérien Road, between Luskville and Quyon.

The 49-year-old man was driving a vehicle with the woman, 47, in the passenger seat. They both died in the crash.

A 33-year-old woman driving another vehicle in the opposite direction was seriously hurt. She was taken to hospital in critical condition.

Both people killed in the crash lived in Aylmer but worked at the Proxim pharmacy in Shawville, Que.

Customer Christine Draper said the staff at the pharmacy are in shock.

"There are no words to describe just how tragic this must be for them," she said.

Highway 148 fatal crash vehicles smashed May 13 2014

Two vehicles crashed into each other on Highway 148 on Tuesday morning, killing two people and critically injuring another. (CBC)

The crash happened on a sharp curve and closed Highway 148 for most of Tuesday.

The investigation into what caused the crash is ongoing, but police said fatigue may have been a factor.

Pontiac mayor Roger Larose wants Quebec's Ministry of Transportation to take a serious look at the highway to find ways to make it safer.

"It's up to the minister of transport now to do the study necessary to try — I know we can't solve everything — but to try to at least prevent some of it," said Larose.

A CBC News analysis of fatal crashes in the region found that from 2001 to 2011 there were nine fatal crashes in a 10 km stretch of the highway from Luskville to the River bridge in Quyon.