Two cars involved in a fatal collision were cleared from Highway 101 near Windsor, N.S., on Thursday. (CBC)

A head-on collision in Nova Scotia Thursday has left one person dead and five injured.

Three of the injured are in critical condition and two are in serious condition, police say.

RCMP Sgt. Brigdit Leger said the crash happened around 1:30 p.m. AT on Highway 101 near Windsor.

Police said a westbound Toyota Camry crossed the centre line and collided with an oncoming Mazda carrying four passengers.

A female passenger in the back of the Mazda was pronounced dead at the scene. The female driver of the Camry was airlifted to hospital in Halifax.

The highway was closed in both directions between exits 5A and 6 for about four hours.

Police are on the scene and an investigation is underway.