The Faculty Association at Cape Breton University has soundly rejected a contract offer from the school.
Members have voted 92 per cent in favour of strike action.
The faculty association represents 160 members including professors, librarians, along with lab and nursing instructors.
Association president Scott Stewart said the main issue is a proposed increase in workload.
He said the offer is unacceptable.
"I hope that message gets through loud and clear and we can be back to the table and work out a deal sooner than later."
Stewart said the vote indicates how his members feel about what CBU is offering them.
"I'm very pleased with the vote. It shows strong support for the position of the negotiating team and the executive."
"It shows that what the employer currently has on the table with respect to faculty teaching workload, where some of our members would see their workload almost double, is completely unacceptable."
The faculty's latest contract ended in June.
Talks between the faculty and the university broke off in early November.
The last faculty strike at the university was in 2000 when CBU was known as the University College of Cape Breton.
That strike lasted for five weeks.
Stewart said both sides have filed for conciliation