A 62-year-old man from Bedford was airlifted to hospital in Halifax after a crash Sunday afternoon at 5 p.m. on Highway 104, east of Truro.
Nova Scotia RCMP said the man was driving a pick-up truck that ran into a tractor trailer parked on the side of the highway, between Mount Thom and Kemptown.
The two people in the tractor trailer were not hurt.
Police describe the man's injuries as serious.
A section of the 104 was closed Sunday while police investigated.
The crash was the second serious crash on Highway 104 on Sunday. Just before 7 a.m. a man died after losing control of his vehicle and crashing his van into the ditch. That crash happened down the road, east of Exit 27 near Broadway. His name has not been released.