The main route between Yellowknife and the south reopened at 8 a.m. Thursday after being closed for 48 hours following a fatal traffic accident.
N.W.T. Hwy 3 was closed for an RCMP investigation since early Tuesday after a head-on collision involving two semi trailer trucks about 80 kilometres north of Fort Providence.
Two people were killed in the crash and a third injured person was transported to Stanton Territorial Hospital in Yellowknife.
One of the trucks involved was believed to have been carrying 1206 boxes of explosives.
The names of the victims have not been released.
Police are controlling access through the section of road where two trucks collided on Tuesday. The bottleneck of trucks and cars are lined up outside of Fort Providence.
"There's about a kilometre worth of vehicles, mostly semis, there's a few private vehicles and they're just letting one vehicle go and then a few minutes later letting another vehicle go," said Yellowknifer Rebecca Alty, who was in the lineup Thursday morning.
It's not known how long police will regulate the highway.
They're asking anyone with more information about what happened on the highway on Tuesday to contact the RCMP in Fort Providence.