He died at a hospital after being taken there from a residence, RCMP spokeswoman Marie York-Condon said in a written statement.
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"When he was home, he was a handyman, he was resourceful," his aunt Mary Anne Jermick'ca told CBC News. "We as a family tried to get him back here, but the street life was something he was so addicted to."
"A lot of times family members tried to get him back here [to Whati], whether it was the winter road, or even paying his plane ticket to come back here," she said.
Nitisiza was homeless and spent much of his time around the Wal-Mart and Tim Hortons in Yellownife. Though he frequented area shelters, staff at the day shelter downtown said they hadn't seen him in a few weeks.
The coroner's office has ordered an autopsy, though RCMP says foul play is not suspected in his death.