Saint John police are treating the death of a 23-year-old man, following an altercation on the lower west side Tuesday night, as a homicide.

The victim died from stabbing injuries he had sustained during a fight on Lancaster Street West shortly after 10:30 p.m.

A 28-year-old man, who was arrested, is expected to appear in provincial court on Thursday morning, Sgt. Jay Henderson said in a statement.

The man will answer "to the most appropriate approved charge that is deemed by the provincial Crown prosecutor's office in consultation with the Saint John Police Force investigators," Henderson said.

A 22-year-old man is also in custody, he said. "We are still investigating his involvement into this matter as the investigation continues."

Saint John police have part of Lancaster Street blocked off as they investigate violent fight

Frederick Cormier Jr., 28, was charged with second degree murder in connection with Spencer Eldridge, 23, being killed in an altercation on Lancaster Street Tuesday night. (Matthew Bingley/CBC)

Another man, aged 61, is being treated at the Saint John Regional Hospital for serious injuries from being run over by a vehicle, said Henderson.

"All individuals are known to one another and this is not considered to be a random act," he said.

The intersection of Tower and Lancaster Streets remains closed as the police investigation continues.

Police responded to a call about a fight involving males on the street in that area on Tuesday, at about 10:37 p.m., said Henderson.

When officers arrived, they found two males with serious injuries, he said.

Both men were transported by ambulance to the Saint John Regional Hospital, where the stabbing victim succumbed to his injuries.

Area resident David Brown says he didn't hear much on Tuesday night, until a heavy police presence arrived.

"We come out and looked, we saw numerous police cars, probably eight or 10 police cars, and two ambulances so we figured something was going on. And we saw them put up the tape, which made me think there must have been a murder," Brown told CBC News.

"They were searching the street, looked like they were looking for evidence."

Carol Lynch says she was cleaning up garbage down the road Tuesday night, but left the area before the incident.

"I'm just real saddened to see, as a Saint Johner … this stuff happening now in our city," she said. "It's frightening to us and you know, we hate to see our young people go down like that."