Police are looking for the public's help in locating two patients missing from a mental health facility in Ontario, now believed to be in New Brunswick.

The pair pose a "significant threat to public safety," police said.

Cara Duval

Cara Duval, 37, who also goes by the last name Donnelly, is just over five feet tall, weighs about 117 pounds, and has brown hair and brown eyes. (RCMP)

Cara Duval, who also goes by Cara Donnelly, and Joseph Pepin, were reported missing from the North Bay Regional Health Centre's mental health and law program on Jan. 22, at about 6 p.m., North Bay police said in a statement. They also advised that the pair may be "dangerous."

The two patients failed to return from permitted off-unit privileges.

Duval and Pepin were both in Hanwell, N.B., on Jan. 27, according to New Brunswick RCMP.

They were identified on video surveillance at an Irving gas station on Hanwell Road at about 2:30 p.m., Cpl. Chantal Farrah said in a statement.

North Bay police are worried about the well-being and safety of Duval and Pepin, as well as the safety of the public.

"Without ongoing monitoring and supervision, both pose a significant threat to public safety," police said in a statement.

The public is advised not to approach Duval or Pepin and to call 911 immediately if they see them.

Joseph Pepin

Joseph Pepin, 39, is six feet tall, weighs 174 pounds, has brown hair and blue eyes. (RCMP)

​Duval, 37, is described as being five feet, one inch tall, 117 pounds, with brown shoulder-length hair, usually kept in a pony tail, and brown eyes.

She was last seen wearing a three-quarter length blue coat with a fur-trimmed hood, pink boots, and a blue and black toque.

Pepin, 39, is six feet tall, 174 pounds, with brown hair and blue eyes.

He may be wearing a short black coat, or a three-quarter length grey coat, jeans, running shoes, and a dark baseball cap.

Duval and Pepin were last seen travelling in a black, four-door, 2006 Volkswagen Jetta, with Ontario licence plate BRVK449.