Winnipeg police are investigating a Friday morning shooting in the area of Main Street and have taken four people from a West End home in connection with the incident.

Officers went to Johnny G's restaurant on Main Street around 2 a.m. and found an injured man.

Main between Broadway and York Avenue was closed for hours after the shooting but was reopened around 6 a.m.

The restaurant remained taped off for much of the day while officers investigated.

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Winnipeg police have taped off Johnny G's restaurant on Main Street. (Meaghan Ketcheson/CBC)

A dark-coloured car in the parking lot was cordoned off with police tape and officers could be seen investigating inside the business.

Yellow police tape had been stretched across the dining-room area of the restaurant.

Const. Eric Hofley would not confirm if the shooting victim was still alive but did say their investigation led them to an address in the 500 block of Sherbrook Street.

An ambulance and police cruisers could be seen surrounding a residence on the block Friday morning.

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Winnipeg police removed at least four persons of interest in the shooting from this Sherbrook Street house on Friday.

At least four people were removed from the scene on Sherbrook, and police said more persons of interest could be removed later in the day.

Mary Ross watched from her window as police removed people from the home. "I seen them grabbing the guys and cuffing them. There were about 8 of them who got picked up. One female."

Police said they anticipated the investigation at both sites would continue for an extended period of time and asked the public to stay away from the areas.

Anyone with information is asked to call investigators at 204-986-6508 or Crime Stoppers at 204-786-8477.