A Hamilton man and a Stoney Creek man were killed after a three-car collision near the intersection of Regional Road 20 and Twenty Mile Road just outside of Smithville.

At 11:48 a.m. on Thursday, a 20-year old woman driving South on Regional Road 20 reportedly lost control of her car, crossed the center line and sideswiped a Northbound 2013 Ford F150 pickup truck driven by a 57-year-old man.

After being hit, the large truck then went over the center line hitting a Southbound 2001 Honda Civic head on. The 21-year-old Stoney Creek driver of the Civic was pronounced dead at the scene. The 21-year-old Hamilton passenger was transported to Hamilton Health Sciences, where he later died.

The 67-year-old man riding in the Ford was also transported to hospital with serious injuries. The woman who lost control of her Mazda had no injuries.

Niagara Regional Police say they cannot determine exactly what caused the initial accident until the accident recreation team finishes investigating.