A man has died after an early-morning fire in central Hamilton.

Around 4 a.m. on Wednesday, fire crews rushed to 249 Cannon St. E after receiving reports of fire and smoke coming from the first floor.

Nobody was in the house when emergency crews arrived. The man had escaped the building and was then transported to hospital in critical condition.

Though he wouldn't give specific details, Hamilton Emergency Medical Services spokesperson Jevon Towns said the victim "had extensive injuries caused by the fire that required aggressive treatment."

The man died from his injuries later Wednesday.

Police have notified his family but have not released the man's name.

Investigators and the Ontario Fire Marshall's department are working to determine the cause of the fire and a post-mortem will be conducted on the victim.

"At the height of the fire we had 35 firefighters on scene," said Claudio Mostacci, public information officer for the Hamilton Fire Department. "The fire started on the first floor, then went into the second and into the attic."

Mostacci said the cause of the fire and the cost of the damages are not yet known.

A neighbour, who was not at home when the fire broke out, said a group of males in their late-teens or early-20s lived at the address. 

Anyone who was in the area at the time of the fire is asked to contact police to aid in the investigation.