A father and son were sent to hospital early Wednesday after a fire gutted their rural Ancaster farmhouse.

Fire crews were called to 1494 Power Line Rd. by Highway 52 around 1:45 a.m. Wednesday.

The father woke up to the smell of smoke and attempted to get his son out of the home but couldn't, Fire Prevention Officer Claudio Mostacci told CBC Hamilton. So the man ran to his neighbour's house about 300 feet away and the two men bolted back towards the fire after calling 911.

By this time, the son had made his way to the front door of the house and was pulled to safety. When fire crews arrived, all of the occupants were out of the house, Mostacci said.

Firefighters encountered "heavy fire and smoke" to the point that they couldn't enter the house, Mostacci said, so they started a "defensive attack" to try to beat down the flames.

In the end, the roof of the home collapsed, "and some of the walls are collapsing too," Mostacci said. Firefighters are still at the home putting out hotspots, he added.

The father and son were taken to hospital to be treated for smoke inhalation. The son was also treated for minor burns. Mostacci said it's believed that their injuries are non-life threatening.

Damage is estimated at around $300,000. The cause of the fire is undetermined at this time, Mostacci said, but it is not being looked at as suspicious.

A stable of horses behind the farmhouse was not harmed in the fire, Mostacci said.