A crash between a pickup truck and a transport truck killed two people and sent a third to hospital in Caledonia early Monday, police say.

Crews were called to the crash site at Highway 6 near 5th Line around 1:45 a.m.

The truck and the pickup collided in the intersection of a four way stop, Const. Mark Foster told CBC Hamilton. The pickup truck was “demolished,” he said, while the transport truck sustained moderate damage on its broad side.

The impact sent the pickup into the south ditch, and the transport truck came to a stop on the shoulder of highway 6. The male driver and male passenger in the pickup were killed and pronounced dead at the scene, police say. Their identities are being withheld until next of kin is notified.

A third male passenger in the pickup was pulled from the wreck by the Haldimand County Fire Department and was rushed to hospital by paramedics.

Foster could not yet say if alcohol was a factor or if anyone was wearing seat belts.

"That's all being looked at, but I can't say one way or the other right now," he said.

The OPP’s technical traffic collision investigator is assisting with the investigation.

Highway 6 is closed to through traffic from Argyle Street to 4th Line. “We expect to be here for another hour or two,” Foster said.