Two people from Hamilton are facing life-threatening injuries after a serious collision in Caledonia.

A black Mazda pickup truck rolled into a ditch near the off ramp for Greens Road after it failed to negotiate the curve, according to a release by the Ontario Provincial Police. The car was travelling southbound on Highway 6, police say.

Two passengers, a 33-year-old female and a 56-year-old male, were sent to hospital by Haldimand County paramedics.

A 44-year-old male was also involved in the collision, but he wasn't injured, police say.

Greens Road is closed to traffic from Argyle Street to the Highway 6 bypass.

The investigation is continuing.

Anyone with information is asked to contact the OPP at 1-888-310-1122, Crime Stoppers at 1-800-222-TIPS (8477) or leave an anonymous online message at www.helpsolvecrime.com, where you may be eligible to receive a cash reward of up to $2000.