Homicide detectives are investigating a hit and run on Whyte Avenue that left one man dead Sunday morning.

Police say an altercation occurred between the drivers of two vehicles at around 2:15 a.m. in the parking lot of the H2O Lounge, on Whyte Avenue and 101st Street.

The 34-year-old driver of one vehicle walked up to the occupants of the other vehicle. When he began to walk away, police say the suspects' vehicle accelerated and struck him before leaving the scene.

The suspects' vehicle, a dark-coloured pickup truck police say was occupied by two Caucasian males, then fled eastbound on Whyte Avenue in the westbound lane and nearly hit a red car.

The truck was last seen near Whyte Avenue and 99th Street.

The 34-year-old man struck in the parking lot was treated and taken to hospital, where he died of his injuries shortly afterwards. 

An autopsy is scheduled for Tuesday.

Police say it's not known if the victim and the suspects knew each other. 

The Edmonton Police Service is asking anyone who may have witnessed this incident or the suspects' vehicle to come forward. The vehicle is described as an older-model, extended-cab pickup truck. It has been modified with a lift kit, oversized tires and clear tail lights. 

Police would also like to speak with the driver of the red car that was nearly hit as the truck fled the scene.