The 31-year-old's body was discovered by her husband in their home in October but now police believe she had been dead for two days.
With help from the medical examiner, it was determined she died between 7-7:30 p.m. on Oct. 24. At the time of the discovery of her body, police said there were signs of a violent incident in the Castleridge home.
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Lee Antoni, Amanda's husband, had been out of town over the weekend and was not considered a suspect.
Antoni was suffering from migraines and police believe she may have run errands over the weekend to local herbalists or pharmacies for medication.
She was driving a four-door 2012 black Chevrolet Cruze.
Anyone who had contact with Antoni on Friday or Saturday is asked to call police at 403-266-1234 or Calgary Crime Stoppers.
Investigators are also asking anyone who witnesses any suspicious activity around her home in the 0-100 block of Castleridge Way N.E. on the Saturday evening to get in touch.
Antoni's death is considered suspicious and the homicide unit is leading the investigation. The behavioural sciences branch of the RCMP has also been called in to assist.