Two young men have been sent to hospital in critical, life-threatening condition after a crash in Calgary's south on Highway 22X at Spruce Meadows Way.

They were travelling in a white Dodge sedan north on Spruce Meadows Way when witnesses say it ran a stop sign and was hit by a cube van going eastbound on Highway 22X.

The male driver of the van is in stable condition.

Calgary police closed eastbound lanes for their investigation.