The powerful painkiller oxycodone was among thousands of pills taken in Tuesday's robbery. (CBC)

Gun-wielding robbers have made off with a large quantity of dangerous drugs from a Vancouver pharmacy, police say.

Two suspects, one brandishing a gun, entered the store in the 2000 block of Commercial Drive about 9:30 a.m. PT Tuesday and forced a male and female employee into the back room, spokeswoman Const. Jana McGuinness said in a release.

McGuinness said the two staff members were tied up and left lying on the floor as the suspects rummaged through the store and then fled on foot.

Both drug users and medical service providers should be aware of the risks posed to people using the stolen drugs, McGuinness said.

Most of the medications stolen in the robbery are powerful painkillers, like oxycodone, methadone and several valium-like drugs.

Thousands of pills and four litres of methadone were among the items taken.

Anyone with information on the robberies or the whereabouts of the pharmaceuticals is asked to contact the Vancouver Police or Crime Stoppers.