One man is in hospital with non-life-threatening injuries after being shot while driving on a busy thoroughfare in South Vancouver Tuesday afternoon.

Vancouver Police said shots were fired at the driver of one car by at least one occupant of another car at around 3:30 p.m. PT as the two vehicles headed east on Southeast Marine Drive, just east of Knight Street.

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Vancouver police are canvassing homes along S.E. Marine Drive after a drive-by shooting Tuesday afternoon. (Richard Zussman/CBC)

Police closed the road between Argyle Street and Victoria Drive to collect evidence, and began canvassing nearby homes seeking witnesses.

"It is too early to determine the motive behind the shooting or if it is gang-related," a written statement from Const. Brian Montague said.

Police are asking anyone who saw either of the two cars involved to contact the major crime section at (604) 717-2541.