Michael Cacoyannis, the Cyprus born-filmmaker and screenwriter who directed the 1964 film classic Zorba the Greek, starring Anthony Quinn, has died at an Athens hospital. He was 89.

Officials at a state-run hospital said Cacoyannis died early Monday of complications from a heart attack and chronic respiratory problems.

Cacoyannis worked with such well-known actors as Melina Mercouri, Irene Papas, Katharine Hepburn, Vanessa Redgrave and Candice Bergen. He was best known internationally for the Zorba the Greek — the 1964 adaptation of Nikos Kazantzakis' novel — which won three Academy Awards, for cinematography, art direction and supporting actress Lila Kedrova.

Composer Mikis Theodorakis's score for the movie remains an enduring Greek anthem.

In the black-and-white movie, a scholarly Englishman played by Alan Bates, travels to the Greek island of Crete to visit a coal mine he inherited. Alexis Zorbas, played by Anthony Quinn, is his grizzled and larger-than-life cook and fixer.

Cacoyannis was nominated for a best director Oscar, Quinn for best actor and Zorba for best picture, but lost out to My Fair Lady.

Cacoyannis was born in 1921 in the Cypriot port of Limassol, when the Mediterranean island was still a British colony. He studied law in London, but soon followed his interest in the arts, working for the BBC's Greek service, studying drama, and eventually getting acting parts in the theatre.

After moving to Athens, Cacoyannis made his debut as a director with Windfall in Athens in 1954. Two years later, he won a Golden Globe for best foreign language film for Stella, starring Mercouri.

Other films include his 1962 feature Ilektra, starring Irene Papas, 1971's The Trojan Woman, starring Katherine Hepburn, and 1999's The Cherry Orchard, starring Alan Bates and Charlotte Rampling.

"His movies received awards at the most important film festivals in the world," Culture Minister Pavlos Geroulanos said. "His work became the vehicle that took Greek culture to every corner of the earth, and served as a source of inspiration for Greek and foreign artists."

Cacoyannis had no children and is survived by his sister Giannoula.