The Material Girl will be taking the stage on football's biggest night.
Madonna, who has sold more than 300 million records, will perform at halftime of the Super Bowl in Indianapolis.
The NFL and NBC announced Sunday during the Detroit-New Orleans game that the Grammy Award-winning singer will highlight the show at Lucas Oil Stadium on Feb. 5.
The show is the most-watched musical event of the year, with more than 162 million in the U.S. tuning in to see The Black Eyed Peas' performance with Slash and Usher in Dallas at halftime of Green Bay's Super Bowl win over Pittsburgh last February.
Madonna, a Rock & Roll Hall of Fame inductee, will join such acts as Bruce Springsteen & The E Street Band, Prince, U2, Paul McCartney, The Who and the Rolling Stones to perform during recent Super Bowls.
She will collaborate with a team from Cirque du Soleil and artists from Moment Factory, another Quebec-based company, to create her halftime act. Also involved is her longtime collaborator, Jamie King, who recently directed the Cirque’s Michael Jackson: The Immortal World Tour.
Madonna, currently in the studio working on a new album, has a new film W.E. that she directed, wrote and produced and will open nationally two days before the NFL's signature event.