John Mayer is the latest singer forced to take a hiatus from performing live because of injured vocal cords.
The seven-time Grammy-winner has cancelled an 18-city tour because of the return of granuloma in his throat, he announced Friday.
Mayer was treated for the same condition and placed on extensive vocal rest in 2011.
The U.S. tour, his first in two years, was to have marked his return to the stage.
"Nothing feels worse than having to break the stage down before the performance, and I mean nothing," Mayer told fans in a statement online.
"I love this band you were going to hear, I love the guys and girls I work with, and the only thing that stops me from devolving into a puddle of tears is knowing that it's a long life, and the greatest gift in the world is being able to create music no matter what the circumstances."
Mayer's retreat from the spotlight will be indefinite, while his voice heals.
The 34-year-old blues-pop singer is known for hits such as Your Body is A Wonderland and Belief. He also recorded One for My Baby with Tony Bennett for the latter's Duets II album.
Mayer's new album Born and Raised, which was postponed after his first treatment for granuloma in 2011, will be released on May 22.