Cholesterol drugs recommended for kids as young as 8: pediatricians
Last Updated: Monday, July 7, 2008 | 3:46 PM ET
The Associated Press
For the first time, an influential U.S. doctors group is recommending that some children as young as eight be given cholesterol-fighting drugs to ward off future heart problems.
It is the strongest guidance ever given on the issue by the American Academy of Pediatrics, which released its new guidelines Monday. The academy also recommends low-fat milk for one-year-olds and wider cholesterol testing.
Dr. Stephen Daniels, of the academy's nutrition committee, says the new advice is based on mounting evidence showing that damage leading to heart disease, the nation's leading killer, begins early in life.
It also stems from recent research showing that cholesterol-fighting drugs are generally safe for children, Daniels said.
Several of these drugs are approved for use in children and data shows that increasing numbers are using them. "If we are more aggressive about this in childhood, I think we can have an impact on what happens later in life … and avoid some of these heart attacks and strokes in adulthood," Daniels said.
He has worked as a consultant to Abbott Laboratories and Merck & Co., but not on matters involving their cholesterol drugs.
Drugs would target obesity, high blood pressure
Drug treatment would generally be targeted for kids at least eight years old who have too much LDL, the "bad" cholesterol, along with other risky conditions, including obesity and high blood pressure.
For overweight children with too little HDL, the "good" cholesterol, the first course of action should be weight loss, more physical activity and nutritional counselling, the academy says.
Pediatricians should routinely check the cholesterol of children with a family history of inherited cholesterol disease or with parents or grandparents who developed heart disease at an early age, the recommendations say. Screening also is advised for kids whose family history isn't known and those who are overweight, obese or have other heart disease risk factors.
Screening is recommended sometime after age two, but no later than age 10, at routine checkups.
The academy's earlier advice said cholesterol drugs should only be considered in children older than 10 after they fail to lose weight. Its previous cholesterol screening recommendations were less specific and did not include targeted ages for beginning testing.
Because obesity is a risk factor for heart disease and often is accompanied by cholesterol problems, the academy recommendations say low-fat milk is appropriate for one-year-olds "for whom obesity is a concern."
Daniels, a pediatrician in the Denver area, agreed that could include virtually all children. But he said doctors may choose to offer the new milk advice only to one-year-olds who are already overweight or have a family history of heart problems.
The academy has long recommended against reduced-fat milk for children up to age two because saturated fats are needed for brain development.
"But now we have the obesity epidemic and people are thinking maybe this isn't such a good idea," said Dr. Frank Greer of the University of Wisconsin, co-author of the guidelines report, which appears in the July edition of Pediatrics, the group's medical journal.
Very young children are increasingly getting fats from sources other than milk, and Greer said the updated advice is based on recent research showing no harm from reduced-fat milk in these youngsters.
