Children's nasal spray poses risk

Health Canada is warning that a nasal spray used to treat bedwetting in children carries a previously unknown risk of a serious, potentially life-threatening effect from increased water retention and decreased sodium levels in the blood.

It said parents should not use nasal spray formulations of desmopressin, including Apotex Inc.s' Apo-Desmopressin Spray, to treat primary nocturnal enuresis, the medical term for nighttime bedwetting.

New safety information shows the sprays are associated with a higher risk of a side-effect known as hyponatremia than oral tablets. Hyponatremia is caused by increased water retention and decreased blood sodium levels, and can lead to seizures or death if not treated.


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